← All peptidesTirzepatide
Dual-agonist — powerful appetite kill and storage blocker, but it stops you getting fatter more than it torches the fat you already carry.
📊 The Protocol
Reconstitute2 mL BAC water per 10 mg vial
DoseStart 1 mg/wk, titrate toward 5–10 mg (15 mg ceiling)
FrequencyOnce weekly
TimingPM, fasted
CycleRun to goal, then maintenance
💪 What it does
Strong appetite suppression and up to ~21% weight loss. It's a 'storage-prevention' drug — it slams the off-switch on fat cells, but has no glucagon arm to actively mobilize the fat you're already holding.
🔬 How it works
Dual agonist: GLP-1 kills appetite while GIP blocks fat storage. It's a wrecking ball for stopping fat gain — but a heat pump like retatrutide is what actually burns stored fat.
💡 Pro tips
Tirz = prevention only; Reta = prevention + mobilization. If your problem is fat already stored, tirz plateaus. 🩺
'Stopped working' switching tirz→reta is usually high cortisol, low thyroid, or fatty liver blocking the glucagon signal — fix those four first. 🩺
Muscle loss is worse than reta (GIP also suppresses mTOR): ~25–30% of weight lost is muscle vs Reta <10%. 🩺
Users hitting >1 g protein/lb kept 91%+ of lean mass; add creatine 5–10 g/day and test testosterone before starting. 🧪
Gallbladder + rebound risk: slowed emptying raises stone risk >30%, and >60% regain most weight after stopping. It's a tool, not a crutch. 🧪