The dual-agonist appetite killer, the "Mounjaro" molecule. It slams the off-switch on fat storage and crushes hunger, so it stops you getting fatter more than it torches the fat you already carry. The clean step before Retatrutide.
Your starting dose
10units
1 mg
3× a week (e.g. Mon / Wed / Fri)
Your insulin syringe is marked 0 to 100. That whole line is 1 mL. Draw to the 10 mark.
01
The protocolHow to mix it, how much to draw, and how long a vial lasts.
The numbers
Vial20 mg
Mix with2 mL BAC water → makes 1 mg = 10 units
Start10 units (1 mg), 3× a week, weeks 1 to 4
Go up by+5 units (0.5 mg) per dose from week 5, only if needed
Frequency3× a week (e.g. Mon / Wed / Fri)
WhenPM, fasted (empty stomach), under the skin
Units made simple: your insulin syringe is marked 0 to 100. That whole line = 1 mL. Just draw to the 10 mark, that's your starting dose. Going up? Draw to 15, then 20. No math.
How long one bottle lasts
At 1 mg 10u ×3/wk~6.5 weeks (30 units a week)
At 3 mg 30u ×3/wk~2 weeks (90 units a week)
At 6 mg 60u ×3/wk~1.1 weeks (180 units a week, the ceiling)
One 20 mg vial = 200 units total. Tirz is dosed 3× a week, so a bottle burns faster than a once-weekly compound, plan your reorders around your dose.
02
What it doesWhat you get, how it does it, and what to know before you run it.
What it does for you
Crushes hungerThe strongest thing you'll feel, appetite drops hard and you eat less without fighting it.
Real weight lossIn its large human trials, most of the loss was fat, with clinically meaningful results in the vast majority of people.
Blocks new fat storageThe GIP arm improves insulin sensitivity and shuts the off-switch on packing on new fat.
Steadier blood sugarIt's the FDA-approved molecule for glycemic control, it helps level out blood sugar and energy.
The credibility anchor: this is one of the very few in this space that's actually FDA-approved, you know it as Mounjaro (diabetes) and Zepbound (weight). It cleared the FDA bar with large human trials.
How it works
It's a dual agonist, it pulls two levers at once. GLP-1 kills your appetite and slows how fast your stomach empties, so you eat less without fighting it. GIP improves insulin sensitivity, amplifies that "full" signal, and blocks new fat storage. What it doesn't have is a glucagon arm, so it's a "storage-prevention" drug: brilliant at stopping fat gain, but it doesn't actively mobilize the fat you're already holding the way Retatrutide does. Think of it as slamming the off-switch on fat storage, versus Reta which also turns on the fat-burning furnace.
What to know before you run it
The receptor ladder: 1 → 2 → 3. Ozempic hits one receptor (GLP-1). Tirz hits two (adds GIP), that's why it out-does Ozempic. Retatrutide hits three (adds glucagon), which is why it's the next step up.
It's the FDA-approved one. Almost nothing in the research-peptide world clears the FDA. Tirz did, twice (Mounjaro and Zepbound). That's your proof-it-works starting point before graduating to Reta.
Prevention, not mobilization. It's great at stopping you getting fatter, but it doesn't torch fat you've already stored, so it plateaus. That plateau isn't the tool failing, it's just its ceiling (no glucagon arm).
Protect your muscle from day one. Like all GLP drugs, some of what you lose can be muscle if you don't lift and eat protein. The scale dropping isn't the whole story, chase the mirror, not the number.
Tirz = prevention. Reta = prevention and mobilization. If your problem is fat you've already stored, tirz plateaus, that's when people graduate to Reta.
When it "stops working" and you switch to Reta and feel nothing, the fix usually isn't the dose, it's your substrate: high cortisol, low thyroid, or a fatty liver blocking the glucagon signal. Fix those first.
NEVER stack it with Retatrutide or Semaglutide, same receptors, so you can't double the fat loss, you just double the organ damage. To break a plateau, add Tesamorelin.
Rebound is real: over 60% of people regain most of the weight after stopping. It's a tool that buys you time to fix your diet and training, not a crutch.
03
How to run itMixing, injecting, what to eat, and what to take alongside it.
Mixing and injecting
Mix: add the 2 mL of BAC water slowly down the side. Swirl gently, never shake.
Store: in the fridge after mixing.
Inject: into belly fat, ~2 inches from your belly button. Pinch, go straight in, push slow. Rotate the spot each time, fresh pin every injection.