The growth-hormone combo. One peptide wakes your pituitary up, the other takes the brakes off, together they rebuild the deep-sleep GH rhythm of a 20-year-old and strip the stubborn fat off your organs. This is the muscle-sparing arm of any fat-loss stack.
Your starting dose
20units
Daily (many run 5 days on / 2 off)
Your insulin syringe is marked 0 to 100. That whole line is 1 mL. Draw to the 20 mark.
01
The protocolHow to mix it, how much to draw, and how long a vial lasts.
The numbers
Vial5 mg Tesamorelin + 5 mg Ipamorelin (both in one vial)
Mix with2 mL BAC water → makes 1 unit = 25 mcg of EACH
Start20 units = 500 mcg Tesa + 500 mcg Ipa, once a day
Range20 to 40 units = 500 to 1000 mcg of each
FrequencyDaily (many run 5 days on / 2 off)
WhenPM / before bed, fasted (empty stomach), under the skin
Cycle12 weeks on → 4 weeks off (the pituitary needs the break)
Units made simple: both peptides live in the same vial, mixed in 2 mL. On your insulin syringe (marked 0 to 100), every 1 unit pulls 25 mcg of Tesa AND 25 mcg of Ipa at once. Draw to 20 = 500 mcg each. Draw to 40 = 1000 mcg each. One draw, both peptides. No math.
How long one bottle lasts
At 500 mcg 20u~10 daily doses per vial
At 1000 mcg 40u~5 daily doses per vial
One vial holds 5 mg of each = 200 units total. At the 500 mcg (20u) starting dose that's ~10 shots, which stretches to about 2 calendar weeks if you dose 5 days a week. A full 12-week cycle needs several vials.
02
What it doesWhat you get, how it does it, and what to know before you run it.
What it does
Visceral fatMelts the deep fat around your organs, Tesamorelin is the one peptide the FDA actually approved (2010) to do exactly this. In the trial it dropped visceral fat ~15%, and it barely touches the fat under your skin, it goes straight for the dangerous kind.
RecompThe "holy grail", build muscle and lose fat at the same time. GH mobilizes the fat, IGF-1 shuttles amino acids into muscle. It's the muscle-sparing arm of any fat-loss run.
Deeper sleepYour biggest natural GH pulse fires during deep sleep, dosing PM rides that wave and deepens it. Usually the first thing people feel.
Recovery and jointsRestores the fast-healing repair speed of your 20s, GH/IGF-1 rebuild connective tissue and shorten recovery.
Skin and anti-agingThe GH→IGF-1 halo drives collagen, better skin quality, elasticity, and firmness.
TriglyceridesImproves your metabolic profile, the same trial saw triglycerides drop meaningfully alongside the fat loss.
Muscle-sparingOn a Retatrutide/GLP run it protects muscle in the deficit, the weight you lose comes off as fat, not lean mass.
How it works
Two levers on the same pump. Tesamorelin is a GHRH analog, it walks up to your pituitary and tells it to release your own pulse of growth hormone (and it's ruthless on visceral fat, the dangerous fat around your organs, ~76% more GH). Ipamorelin mimics ghrelin and, more importantly, releases the somatostatin "brake", your body's built-in GH off-switch, without touching cortisol or prolactin. Pull both levers at once and the GH pulse is multiplicative (~+156% vs either one alone). More GH → more IGF-1 → protein synthesis, so on a fat-loss stack your weight comes off as fat while muscle stays. Crucially, this is your own GH firing in its natural pulse, the opposite of injecting HGH, which flatlines the hormone and shuts your own pituitary down.
What to know before you run it
It's the only FDA-approved one of its kind. Tesamorelin was approved back in 2010 (as Egrifta) specifically to reduce fat around the organs, the strongest credibility any peptide on this shelf has.
Why it targets belly/organ fat. Visceral fat cells carry more GH receptors than the fat under your skin, so when GH goes up, it burns the deep fat first. That's why it hits the "hard round gut" that won't budge with diet.
Your GH tanks as you age. You lose roughly half your growth hormone by 60. This turns the tap back toward your 25-year-old levels, without a synthetic hormone.
Ipamorelin is the "clean" one. It's the most selective GH peptide ever made, it fires GH with no cortisol, no prolactin, and no hunger spike. A sniper, not a grenade.
Dose it ONCE a day, period. The peptide clears in ~30 min but the IGF-1 cascade it kicks off runs ~8 hours, you're not dosing the peptide, you're dosing the cascade.
It's insulin that blunts the pulse, not "food near the injection." Fasted is the whole game, a carb-heavy meal right before your shot flattens it.
Substrate first: no zinc, magnesium, D3+K2, or protein = a weak pulse. Give the GH something to build with.
Water retention the first 5 to 7 days is expected, then it resolves. Manage with sodium/potassium, not more water, and don't panic-quit over it.
This is the muscle-sparing arm of a Retatrutide run, it keeps you from losing muscle while the fat comes off.
03
How to run itMixing, injecting, what to eat, and what to take alongside it.
Mixing and injecting
Mix: add the 2 mL of BAC water slowly down the side of the vial. Swirl gently, never shake. Cloudy = ruined.
Store: in the fridge after mixing.
Inject: into belly fat, ~2 inches from your belly button. Pinch, go straight in, push slow. Rotate the spot, fresh pin every time.