The easiest way to make your own growth hormone again. It taps your pituitary to fire natural, pulsatile GH, the recovery, deep sleep, lean mass, and younger skin of your 20s, without the shutdown risk of injecting HGH. The gentlest, most beginner-friendly door into GH optimization.
Your starting dose
5 to 10units
500 to 1000 mcg
Once a day, under the skin
Your insulin syringe is marked 0 to 100. That whole line is 1 mL. Draw to the 5 to 10 mark.
01
The protocolHow to mix it, how much to draw, and how long a vial lasts.
The numbers
Vial10 mg
Mix with1 mL BAC water → makes 100 mcg = 1 unit
Dose5 to 10 units (500 to 1000 mcg)
FrequencyOnce a day, under the skin
WhenPM before bed, fasted, or fasted AM (goal-dependent)
Cycle12 weeks on / 4 weeks off
Units made simple: your insulin syringe is marked 0 to 100. That whole line = 1 mL. Just draw to the 5 mark, that's 500 mcg, your starting dose. Want the full pulse? Draw up to the 10 mark (1000 mcg). No math.
How long one bottle lasts
At 500 mcg 5u~20 days
At 1000 mcg 10u~10 days
One 10 mg vial = 100 units total (10,000 mcg). It's dosed daily, so at the 500 mcg starting dose a bottle runs about 20 days, plan on 4 to 8 bottles for a full 12-week cycle.
02
What it doesWhat you get, how it does it, and what to know before you run it.
What it does
Your own GHIt stimulates your own pituitary to pulse growth hormone naturally, the opposite of injecting HGH, which shuts your own production down. No shutdown, no PCT, your natural rhythm stays intact.
Deeper sleepAround 70% of your GH releases in deep sleep, Sermorelin restores that nightly pulse and deepens it. The most consistently-felt effect, usually first.
RecoveryFaster tissue repair, GH/IGF-1 rebuild joints and connective tissue and shorten recovery.
Skin and hairThe GH→IGF-1 collagen halo, younger-looking skin and hair. The "looks good, not just jacked" lane.
Lean and vitalityModest lean-mass support and an anti-aging/energy lift as it restores a youthful GH rhythm. It primes the body, gentle by design.
Beginner-friendlyThe gentlest GH peptide with the fewest rules and the mildest side-effect profile, the ideal first step into GH optimization.
How it works
Sermorelin is a GHRH analog, the natural "growth-hormone-releasing" signal your hypothalamus already uses. It "makes a reservation" with your pituitary to release a pulse of your own growth hormone, which converts downstream into IGF-1, the messenger that actually drives recovery, lean mass, fat mobilization, deeper sleep, and cellular repair. Because it's a secretagogue (your own pulsatile GH) and not injected HGH, it keeps your natural rhythm intact. Trevor's warning on synthetic HGH: it suppresses your own production ~89% in 4 weeks and can permanently kill your pulsatile secretion, "the most ridiculous thing you can ever stick in your body if you have an option." Sermorelin is the opposite: it wakes your own system up.
What to know before you run it
It's the one with a real FDA-approval history. Sermorelin was actually FDA-approved (as Geref), it was pulled from the market in 2008 for business reasons, not safety. That "it was FDA-approved" story is 100% true and makes it a great first peptide for a skeptic.
You make your own, not a foreign hormone. It's a near-copy of the exact GHRH signal your body already uses. Your GHRH pulse fades as you age; Sermorelin restores the signal you used to make.
Why pulsatile beats injected HGH. Injecting HGH forces a flat, constant level and shuts your pituitary down (~89% in 4 weeks). A secretagogue like Sermorelin keeps the natural on/off pulse, and your body's feedback loop stays in charge, so you can't flood yourself.
It's gentle by design. Its short half-life fires a clean, discrete pulse rather than a big slam, the fewest side effects of any GH peptide, at the cost of being the mildest. Add Ipamorelin later when you want more.
Run it fasted, PM before bed, it rides your natural overnight GH surge, which is when most of your GH is released anyway, for the deepest sleep and recovery.
Weak alone, strong stacked. Sermorelin is the accelerator (GHRH); a GHRP like Ipamorelin releases the brake (somatostatin). Pull both levers and you get a bigger, more natural pulse than either can alone.
Dose low, titrate up. If you retain water, the dose is too high, drop it and creep back up. More is not better here.
This is the easiest, gentlest entry into GH, fewest rules, beginner-friendly results. Give it time: better sleep shows up first (days to ~2 weeks), body composition builds over months. Don't chase it with a bigger dose, cycle it (12 on / 4 off) instead.
03
How to run itMixing, injecting, what to eat, and what to take alongside it.
Mixing and injecting
Mix: add the 1 mL of BAC water slowly down the side of the vial. Swirl gently, never shake.
Store: in the fridge after mixing. Keep it cold, keep it out of light.
Inject: into belly fat, ~2 inches from your belly button (thigh also works). Pinch, go straight in, push slow. Rotate the spot, fresh pin every time.
Empty stomachNo food for ~2 hrs before and after your shot. Take it fasted, before bed is the classic window.
Why"The number one thing growth hormone hates is carbohydrates." It's insulin, not food itself, a blood-sugar spike around your dose suppresses the GH pulse by roughly half.
OtherwiseNo special diet, eat normally through the day, high protein so the extra GH has material to build with.
Take these alongside it
Pair itSermorelin is a GHRH, the "release more GH" signal. Stack it with a GHRP like Ipamorelin (a separate receptor) for roughly 40% more GH than either alone.
GH supportZinc 30 to 50 mg, magnesium glycinate 400 to 500 mg, D3 5 to 10k IU and K2, the minerals GH output runs on.
Amino baseArginine 2 to 3 g and glutamine (optional) at your night dose can amplify the natural GH release.