← All peptidesRetatrutide
The triple-agonist — the strongest fat-loss compound there is, and the only one that actively burns stored fat.
📊 The Protocol
Reconstitute1 mL BAC water per 10 mg vial
DoseStart 0.5–1 mg/wk, titrate +0.5 mg. Sweet spot 2–4 mg (15 mg is a ceiling, not a target)
FrequencyOnce weekly
TimingPM, fasted
CycleRun to goal, then maintenance
💪 What it does
Melts fat — preferentially the dangerous visceral fat around your organs — while sparing muscle far better than Ozempic or Mounjaro. ~24% bodyweight loss in trials, most of it pure fat.
🔬 How it works
Triple agonist: GLP-1 kills appetite, GIP browns fat and raises energy expenditure 10–15%, and the glucagon arm forces your liver to torch stored fat. That glucagon 'gas pedal' is what no other GLP-1 has.
💡 Pro tips
The dose trap: 4 mg → 8 mg is 'a 5% increase in fat loss and a 300% increase in side effects.' Above 4 mg receptors are saturated — more is just organ damage. 🩺
It NEEDS carbs — running it keto sabotages it. The glucagon arm requires carbohydrate; without it, gluconeogenesis eats your own muscle. 🩺
'It stopped working' = you didn't titrate, not tolerance. But if you can't finish meals, taper DOWN — that's over-dosing. 🧪
The liver double-edge: glucagon dumps fatty acids at 400–600% of normal. Cap loss at ~1%/wk; GGT is the earliest warning marker nobody checks. 🩺
NEVER stack with tirzepatide/semaglutide — you can't double-activate a saturated receptor. To break a plateau, add Tesamorelin instead. 🩺