The strongest fat loss compound there is, and the only one that actively burns stored fat. It melts fat, especially the dangerous fat packed around your organs, and it holds onto muscle far better than Ozempic or Mounjaro.
Your starting dose
15units
1.5 mg
Every 6 days. PM, fasted, under the skin.
Your insulin syringe is marked 0 to 100. That whole line is 1 mL. Draw to the 15 mark. Going up later? Draw to 20. No math.
Already lean, or just holding a result you already got? There is a lower dose for that. Skip to 04 Maintenance.
01
The protocolHow to mix it, how much to draw, and how long a vial lasts.
The numbers
Vial20 mg
Mix with2 mL BAC water, which makes 1 mg = 10 units
Start15 units (1.5 mg), every 6 days
Go up by+5 units (0.5 mg) after 2 to 3 weeks, and only if appetite suppression fades
Sweet spot15 to 20 units (1.5 to 2 mg), where most people get great results
WhenPM, fasted on an empty stomach, under the skin. Every 6 days. It stays in your system about 6 to 7 days
How long one bottle lasts
1.5 mg 15uAbout 2.5 months, the starting dose
2 mg 20uAbout 2 months
4 mg 40uAbout 1 month
One 20 mg vial is 200 units total. Retatrutide is dosed every 6 days, so at the 1.5 mg starting dose one vial runs you about 2.5 months.
02
What it doesWhat you get, how it does it, and what to know before you run it.
What you get
Fat, not muscleThe majority of what comes off is fat mass. The glucagon arm and eating carbs protect lean tissue far better than Ozempic or Mounjaro.
Appetite goneFood digests slower and hunger drops, so you eat less without white knuckling it.
Visceral fatHits the dangerous fat packed around your organs at roughly twice the rate of the fat under your skin.
Metabolic resetImproves blood sugar and insulin sensitivity and supports a healthy liver. Research shows it strips liver fat hard. Weight loss is almost the side effect of the metabolism getting fixed.
Burn stays upRaises how much energy you burn instead of tanking your metabolism the way a crash diet does.
The number people cite: in a human research trial, participants lost up to about 24% of their body weight over roughly a year, the strongest fat loss figure of any GLP compound to date.
How it works
It is a triple agonist, the first single molecule that hits three receptors at once. GLP-1 kills your appetite and slows how fast your stomach empties, so food fills you up for longer. GIP browns your fat, raises how much energy you burn by 10 to 15%, and helps send carbs toward muscle instead of fat storage. And the glucagon receptor, which no other GLP-1 has, tells your liver to actively burn stored fat instead of only blocking new fat from going on. That third receptor is the whole reason it out works Ozempic, which hits one, and Mounjaro, which hits two.
What to know before you run it
Three receptors, not one. Ozempic hits one, Mounjaro hits two, this hits three. Each one added does something the last could not, and that is the whole story of why it is stronger.
More is NOT better. This is the dose trap. Going from 4 mg to 8 mg is roughly a 5% increase in fat loss and a 300% increase in side effects. Above about 4 mg your receptors are basically full, so precision beats intensity. Most people never need more than 2 to 4 mg.
It literally needs carbs to work right. That glucagon arm runs on carbohydrate. Run this keto or fasted and it turns around and burns your own muscle for fuel instead. This is the one time "eat your rice" is the actual protocol.
One shot holds a steady level. It stays in your system about 6 to 7 days, so you never drop to zero between shots. Splitting it into daily injections adds nothing but more needles. Running a lower dose is a different thing, see 04 Maintenance.
"It stopped working" usually means you did not titrate. That is not tolerance. But if you cannot finish meals, taper DOWN.
Never stack it with Tirzepatide or Semaglutide. Same receptor, so you cannot double the effect, you only double the organ damage. To break a plateau, add Tesamorelin.
03
How to run itMixing, injecting, what to eat, and what to take alongside it.
Mixing and injecting
Mix. Add the 2 mL of BAC water slowly down the side. Swirl gently, never shake.
Store. In the fridge after mixing.
Inject. Into belly fat, about 2 inches from your belly button. Pinch, go straight in, push slow. Rotate the spot each week, fresh pin every time.
First time injecting? Read Injection Basics. It takes 60 seconds and it barely hurts.
Your diet, and this one is not optional
Eat45 to 55% of calories from slow carbs. Rice, potatoes, oats.
NeverKeto or fasted.
Protein1 to 1.5 g per lb of goal bodyweight, which protects muscle.
Take these alongside it
LiverIt works your liver hard. TUDCA, NAC, magnesium glycinate and zinc.
MuscleCreatine 5 to 10 g, vitamin D3, B12.
Prime firstRun MOTS-c for 4 to 6 weeks before, so your body can handle the fat release.
MaintenanceHolding a result instead of chasing one, on a fraction of the dose.
Your maintenance dose
5units
0.5 mg
Every 6 days. PM, fasted, under the skin. Same as always.
Same syringe, same line. Draw to the 5 mark. Up to 10 if you still want a slow drip down. That is a third to two thirds of a fat loss shot.
The numbers
Dose5 to 10 units (0.5 to 1 mg)
WhenEvery 6 days, same as the fat loss protocol
Settle timeAbout 4 to 5 weeks before you know where you actually sit
Find your numberStart at 5. If the scale creeps, go to 7. Adjust once a month, not once a week
Who this is for
You finished a runAnd you want to keep what you got instead of watching it come back.
You are already leanAnd you only want the last bit off, slowly, without the appetite crash.
You don't want a full protocolYou want the smallest thing that works, not the strongest thing available.
What it holds, and what it does not
It holds your appetite set point. That is the thing that fades first when you stop, and it is the actual reason weight comes back. It is biology, not willpower.
It does not hold your muscle. Protein and lifting do that, on the compound or off it. Nothing about a lower dose changes that job.
The carbs rule still applies. That glucagon arm runs on carbohydrate at any dose. Lower does not mean you can run it keto or fasted.
Be straight about this range
There is no trial that defines a maintenance dose for this compound. The lowest dose ever studied was 1 mg, and over a year that still took close to 9% of bodyweight off people. So treat 1 mg as the top of this range, not the middle. Start at 5 units, give it a month, and find your own number. Anyone quoting you a precise maintenance dose is guessing.
This is not a gentler way to start
If you have real weight to lose, this dose will waste your time and your bottle. Start at 15 units and run the protocol at the top of this page. Come back here when you are done.
If you would rather just come off
Then come off. There is no taper you have to do. It clears out of you over about a month on its own, so stopping is a fade, not a cliff. Know what happens on the way down though. With the closest compounds we have data on, people regained roughly two thirds of what they lost inside a year of stopping, because the appetite set point came back with them. A maintenance dose is one way to hold the line. Eating enough protein, lifting, and sleeping properly hold it whether you stay on the compound or not.