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NAD+
The cellular fuel tank. It's the coenzyme that powers every energy and repair reaction in your cells — and the single thing that refills what MOTS-c burns through while it builds you new mitochondria. If you're crashing, tired, or foggy, this is the baseline.
📊 The Protocol
Vial500 mg
Mix with5 mL BAC water (use "No-Sting") → makes 1 mg = 1 unit
Start5 units (5 mg) — go slow the first week
Go up by+5 units (5 mg) per dose until it feels comfortable
Sweet spotup to 25 units (25 mg) per shot — the top of the range
Frequency3×/week (Mon / Wed / Fri) — or daily if you're running it to fix a MOTS-c crash
WhenAM, fasted, under the skin (belly) or into muscle
CycleRun a total of ~1,000 mg (2 vials), then a 4-week break, repeat
🧮 Units made simple: your insulin syringe is marked 0–100. That whole line = 1 mL. At this mix, 1 mg = 1 unit — so a 25 mg dose = draw to the 25 mark. No math. Expect a warm tingle as you go up — that's normal, back off if it's too much.
⏳ How long one bottle lasts
At 5 mg 5u100 doses per vial (~8 months at 3×/week)
At 25 mg 25u20 doses per vial (~7 weeks at 3×/week)
At 25 mg 25u daily20 doses per vial (~3 weeks)
One 500 mg vial = 500 units total. Because 1 mg = 1 unit here, just divide 500 by your dose to see how many shots you get.
💉 How to take it
Mix: add the 5 mL of BAC water slowly down the side of the vial. Swirl gently — never shake.
Store: in the fridge after mixing.
Inject: into belly fat (~2 inches from your navel) or into muscle. Pinch, go straight in, push slow — pushing fast is what makes it sting. Rotate the spot, fresh pin every time.
Normal: the site may burn or go a little red, and you may feel a flush/tingle — it fades. Push slower and it's milder.
🍽️ Your diet
Carbs on boardIf you're pairing it with MOTS-c, you NEED clean carbs (rice, potato, oats) — building mitochondria without them stalls the whole thing.
ProteinEat real protein (steak/eggs, not pea-protein shakes) — your body rebuilds NAD+ from it.
Boost it naturallyIntermittent fasting (18:6), exercise, and real sleep all raise your own NAD+. Cut processed food + fructose, which drain it.
💊 Take these alongside it
Electron carrierCoQ10 / ubiquinol 200 mg daily with a fatty meal — new mitochondria can't run without it.
ATP cofactorMagnesium glycinate 400–500 mg at night (helps make ATP, also helps sleep).
Antioxidant supportZinc 20 mg + selenium 200 mcg daily protect the new mitochondria while they build.
Pair it withMOTS-c — NAD+ is what kills the MOTS-c fatigue dip. Run them together through the ~8-week build, then taper.
⚠️ Watch for / red flags
Feeling worse on it? That means the dose is too high OR the product is junk. Go DOWN — don't push through it.
More is NOT better. Past your threshold you just trigger desensitization and shut the benefit off. The sweet spot beats the max.
Flush / tingle / warm rush is normal and fades — but if it's intense, you pushed too fast. Slow the injection right down.
It's a bridge, not forever. Once your mitochondria are rebuilt, demand drops back to baseline and you taper off the daily shots.
🚫 Who should NOT take it
Pregnant, breastfeeding, or trying to conceive
You have an active cancer diagnosis — clear it with your oncologist first
You're managing a serious medical condition or on prescription meds — talk to your doctor before starting
You've reacted badly to injected NAD+ before
🔬 How it works
NAD+ is a coenzyme your body uses in ~500 reactions, and it's the electron shuttle that lets your mitochondria actually make ATP (energy). It's also the fuel for sirtuins — your DNA-repair and maintenance crew. Levels drop ~50% by age 50–60, which is a big part of why energy, recovery, and clarity fade with age. When MOTS-c signals your body to build a whole new batch of mitochondria, that burns through your NAD+ pool fast — so refilling it isn't optional, it's the "payroll" that funds the repair crew MOTS-c commands.
💡 Pro Tips
NAD+ is the FIX for the MOTS-c crash. That crash is NAD+ depletion, not ATP — daily subq NAD+ turns ~3 weeks of misery into ~7 days.
It MUST be subcutaneous, not oral — your gut destroys it. Injected NAD+ is far better than NMN/NR pills.
Run it daily (25 mg) during a MOTS-c rebuild; on its own for general energy/anti-aging, 3×/week is plenty.
Pair it first thing AM with CoQ10 — the two work the same energy chain.
⚡ The Energy Lab · @hybrid.kyle
Medical Disclaimer. The Energy Lab by Hybrid Kyle provides education and information only — this is not medical advice, diagnosis, or treatment. The compounds referenced are sold for research and educational purposes and are not FDA-approved to prevent, treat, or cure any condition. Nothing here replaces a licensed healthcare provider. Always consult your doctor before starting any peptide, supplement, or protocol — especially if you're pregnant, nursing, taking medication, or managing a health condition. Individual results vary; you're responsible for your own health decisions. © 2026 Hybrid Kyle · The Energy Lab.